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POSTED September 14, 2012 9:34 p.m.

DETROIT (1-0) At SAN FRANCISCO (1-0)

Sunday, 5:20 p.m., NBC

OPENING LINE — 49ers by 6 1/2

RECORD VS. SPREAD — Detroit 0-1; San Francisco 1-0

SERIES RECORD — 49ers lead 36-27-1

AP PRO32 RANKING — Lions, No. 13; 49ers, No. 2

LAST MEETING — 49ers beat Lions, 25-19, Oct. 16, 2011

LAST WEEK — Lions beat Rams 27-23; 49ers beat Packers 30-22

LIONS OFFENSE — OVERALL (4), RUSH (17T), PASS (1)

LIONS DEFENSE — OVERALL (2), RUSH (8), PASS (4)

49ERS OFFENSE — OVERALL (11), RUSH (2), PASS (23)

49ERS DEFENSE — OVERALL (11), RUSH (5), PASS (19)

STREAKS, STATS AND NOTES — San Francisco 12-1 in series at Candlestick Park. ... Niners handed Lions first loss in 2011 following 5-0 start. ... 49ers have six straight regular-season games without turnover. ... Last year's penalty-filled game featured four lead changes in second half. San Francisco fell behind 10-0 in first quarter. ... 49ers QB Alex Smith has gone 185 straight passes without INT, best in franchise history, passing Hall of Famer Steve Young's 184. Smith had 125.6 QB rating last week. Niners 11-0 in games when he has rating over 100.0. ... San Francisco kept Calvin Johnson out of end zone in 2011 game after he became NFL's first player with nine TD catches in initial five games of a season. Johnson still had seven catches for 113 yards, Brandon Pettigrew with eight catches for 42 yards and TD. ... Last year's game at Ford Field ended with Jim Harbaugh's hard backslap and handshake that irked Jim Schwartz and they had to be separated. Both say no bad blood now. ... Lions still had two top starting DBs, Louis Delmas (knee) and Chris Houston (ankle), on injury report after each missed opener. ... San Francisco K David Akers booted 63-yard field goal last week to tie NFL record and is 3 for 3 on the season. Hit 55-yarder last year vs. Lions on way to single-season NFL mark of 44. ... Three-time Pro Bowl RB Frank Gore had first 100-yard game of year at Green Bay after getting a franchise-best five straight during one stretch in 2011. ... Detroit's Matthew Stafford, No. 1 pick from the 2009 draft, threw three interceptions before halftime for first time last week. Still wound up with 355 yards passing. ... Niners Michael Crabtree matched career high with nine receptions for 77 yards in '11 meeting. ... Lions 2012 starting offensive line leads NFL in games started for their current team with 494 regular-season and five in playoffs for 499. ... Detroit RB Mikel Leshoure must sit out second game of two-game suspension to start year for violating NFL's substance-abuse policy.

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