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DETROIT (AP) — Alex Avila's two-run homer with two outs in the bottom of the 11th inning gave the Detroit Tigers a wild 13-12 victory over Boston on Sunday, leaving the Red Sox winless in three games under new manager Bobby Valentine.

Detroit trailed 10-7 when Miguel Cabrera tied the game with a three-run shot off Alfredo Aceves in the ninth. Boston then scored twice in the 11th, but Mark Melancon (0-2) couldn't hold the lead.

Cabrera and Prince Fielder singled before a wild pitch sent Cabrera to third and Delmon Young's sacrifice fly cut the margin in half. Avila followed with a drive to right and Cody Ross tried to make a leaping catch, but the ball appeared to hit a restraining gate just above the wall before caroming back onto the field.

Duane Below (2-0) got one out for the win — even though Detroit manager Jim Leyland said he wouldn't be available — and the Tigers completed a three-game sweep in a game that lasted 4 hours, 45 minutes.

Boston is without newly acquired closer Andrew Bailey, who had surgery on his right thumb. Melancon and Aceves are the primary candidates to close in Bailey's absence, and both blew saves on Sunday.

RAYS 3, YANKEES 0

ST. PETERSBURG, Fla. (AP) — Jeremy Hellickson came within one out of a three-hitter on his birthday and Tampa Bay beat New York to complete a season-opening sweep and match the best start in club history.

Carlos Pena and Jeff Keppinger homered for Tampa Bay, which also started with three consecutive wins in 2002.

New York is 0-3 for the first time since 1998, when it went on to win 114 games and the World Series. The last time the Yankees and Red Sox both opened with three straight losses was 1966, according to STATS LLC.

Celebrating his 25th birthday, Hellickson (1-0) limited the Yankees to three doubles. The 2011 AL Rookie of the Year walked four, struck out four and was one out from his third career complete game and second shutout when he was replaced by Fernando Rodney after 118 pitches.

Rodney, an offseason addition to the bullpen, got the win in Friday's season opener and then earned saves in each of the next two games.

Pena homered off starter Phil Hughes (0-1) in the third. Another offseason acquisition, Keppinger hit a solo shot off Boone Logan in the sixth.

RANGERS 5, WHITE SOX 0

ARLINGTON, Texas (AP) — Matt Harrison pitched six scoreless innings, and Josh Hamilton, Adrian Beltre and David Murphy homered to power Texas over Chicago.

Hamilton's first homer of the season was a 441-foot blast that landed in the second deck of seats high above the Rangers' bullpen in right-center field. That was leading off the sixth against Gavin Floyd (0-1), putting Texas up 4-0 right after Harrison threw his last pitch.

Harrison (1-0) worked out of a jam in the top of the sixth when A.J. Pierzynski struck out with two runners on base. He struck out three and walked two while giving up four hits.

Mark Lowe, Robbie Ross and Koji Uehara each worked a scoreless inning of relief for Texas

Floyd gave up five runs — four earned — in 5 2-3 innings, striking out three and walking two.

ORIOLES 3, TWINS 1

BALTIMORE (AP) — Jason Hammel took a no-hitter into the eighth inning in his Baltimore debut and the Orioles beat Minnesota for a three-game sweep.

Hammel (1-0) faced the minimum 21 batters through seven innings, allowing two walks, before Justin Morneau ended the no-hit bid with a leadoff double off the right-field wall in the eighth.

Josh Willingham followed with an RBI double and Sean Burroughs drew a one-out walk before Hammel finished by striking out Luke Hughes and retiring Ben Revere on a fly to right.

Jim Johnson worked the ninth to earn his second save and complete the two-hitter.

Hammel came to Baltimore in February in the trade that sent Jeremy Guthrie to Colorado.

J.J. Hardy homered for the Orioles, who have won seven straight over the Twins by a collective score of 39-9. The streak began with a four-game sweep last August in Minnesota.

The Twins scored only five runs in the series. The only other times Minnesota started 0-3 were 1969 and 1981.

Twins starter Anthony Swarzak (0-1) performed admirably in place of Liam Hendriks, hospitalized over the weekend with apparent food poisoning. Swarzak, normally a long reliever, gave up one run and four hits in five innings.

ROYALS 7, ANGELS 3

ANAHEIM, Calif. (AP) — Eric Hosmer and Billy Butler homered and drove in three runs apiece, and Kansas City beat Los Angeles to take two of three in their season-opening series.

Jonathan Sanchez (1-0) got through five innings to win his first start with the Royals, who dampened the revamped Angels' much-hyped home debut with two victories after getting shut out on opening day.

Albert Pujols went 2 for 3 with a double and two walks, driving in his first run for the Angels with a first-inning groundout. Los Angeles' new $240 million slugger went 3 for 10 with two doubles in his first three games at Angel Stadium.

Vernon Wells homered in the eighth, but Ervin Santana (0-1) yielded seven hits and six runs while failing to get out of the sixth inning.

With two on, Jonathan Broxton struck out Torii Hunter, Wells and Kendrys Morales for an impressive finish to his first save for the Royals.

INDIANS 4, BLUE JAYS 3

CLEVELAND (AP) — Carlos Santana hit two home runs on his 26th birthday, Derek Lowe pitched seven strong innings and Cleveland beat Toronto for its first win.

Santana opened the second inning with a drive to center. He connected a second time off Joel Carreno (0-1) in the fifth, a two-run shot to right that broke a 2-all tie.

It was Santana's second career multihomer game. On his last four birthdays, including two years in the minors, Santana is 10 for 17 with five homers and 13 RBIs.

Lowe (1-0) got 15 outs on grounders and allowed two unearned runs in his Indians debut. Chris Perez pitched a shaky ninth for the save. Toronto loaded the bases, but Perez got slugger Jose Bautista to pop out to end it.