EAST RUTHERFORD, N.J. (AP) — Peyton Manning again beat younger brother Eli, throwing two touchdown passes in leading the Denver Broncos past the New York Giants 41-23 on Sunday.

The older Manning is 3-0 in the NFL against his sibling, with the other two victories coming when Peyton was with the Colts. He got this win with a huge boost from Knowshon Moreno, who rushed for two touchdowns and 93 yards. Denver (2-0), which has won 13 straight regular-season games, rushed for 109 yards altogether.

PACKERS 38, REDSKINS 20: GREEN BAY, Wis. (AP) — Aaron Rodgers threw for a career-high 480 yards and four touchdowns and Green Bay used a big first half to win its home opener.

Redskins quarterback Robert Griffin III threw for 320 yards and three second-half touchdowns. Pierre Garcon had 143 yards receiving and a touchdown.

But it was too little, too late after Washington (0-2) fell short again after being outplayed early for a second straight week.

CHARGERS 33, EAGLES 30: PHILADELPHIA (AP) — Philip Rivers threw three touchdown passes to Eddie Royal, and Nick Novak kicked a 46-yard field goal with 7 seconds left, spoiling Chip Kelly’s home debut.

Michael Vick threw for a career-best 428 yards and two touchdowns and ran for a score. But a porous Eagles defense couldn’t stop Rivers all day.

BEARS 31, VIKINGS 30: CHICAGO (AP) — Jay Cutler threw a 16-yard touchdown pass to Martellus Bennett with 10 seconds left.

Minnesota’s Blair Walsh had just kicked a 22-yard field goal with 3:15 remaining when Chicago took over at its 34. Cutler, who led the Bears back from an 11-point deficit in a season-opening win over Cincinnati, struck again.

CHIEFS 17, COWBOYS 16: KANSAS CITY, Mo. (AP) — Alex Smith threw for 223 yards and two touchdowns, and the Kansas City defense held when it needed to in the fourth quarter.

Jamaal Charles ran for 55 yards and caught a touchdown pass for the Chiefs, who made new coach Andy Reid a winner in his home debut. The Chiefs also matched their victory total from all of last season by starting 2-0 for just the second time since 2005.

TEXANS 30, TITANS 24, OT: HOUSTON (AP) — Rookie DeAndre Hopkins caught a 3-yard touchdown pass in overtime to cap Houston’s comeback win.

With Andre Johnson out after being shaken up in the fourth quarter, Hopkins reached above Jason McCourty and pulled in the pass from Matt Schaub to give Houston the victory.

BILLS 24, PANTHERS 23: ORCHARD PARK, N.Y. (AP) — Rookie EJ Manuel hit Stevie Johnson for a 2-yard touchdown pass with 2 seconds left.

The touchdown capped a nine-play, 80-yard drive in which the first-round draft pick completed 6 of 8 attempts for 51 yards. Manuel also got help on third-and-6 from Carolina’s 29, when Panthers linebacker Luke Kuechly was penalized for pass interference with 14 seconds left.

Two plays later, Manuel found Johnson alone in the left corner as Buffalo (1-1) bounced back from a 23-21 season-opening loss to New England.

DOLPHINS 24, COLTS 20: INDIANAPOLIS (AP) — Ryan Tannehill threw for 319 yards and one touchdown, and the Dolphins defense held off yet another Colts comeback bid.

Charles Clay gave Miami the lead for good with a 1-yard TD run late in the third quarter. The Dolphins are 2-0 for only the second time since 2004.

Indianapolis (1-1) lost at home for the first time in 12 months and only the second time in Andrew Luck’s brief NFL career.

SAINTS 16, BUCCANEERS 14: TAMPA, Fla. (AP) — Garrett Hartley kicked a 27-yard field goal as time expired to give New Orleans a weather-delayed victory over Tampa Bay.

Drew Brees shrugged off throwing an interception that was returned to touchdown to give Tampa Bay the lead to complete three straight passes for 54 yards to lead the Saints (2-0) into position to win.

He finished 26 of 46 for 322 yards, but was sacked four times and intercepted twice.

The game was delayed 69 minutes by lightning in the first quarter.

FALCONS 31, RAMS 24: ATLANTA (AP) — Julio Jones hauled in 11 passes for 182 yards, including an 81-yard touchdown, and Atlanta held on for its first win of the season.

Matt Ryan threw for 374 yards and two scores despite taking quite a beating behind the Falcons’ shaky offense line. Jason Snelling clinched it for the Falcons (1-1) with an 11-yard touchdown run with 6:18 remaining — Atlanta’s longest play of the day on the ground.

The Rams (1-1) fell behind 21-0 when Osi Umenyiora returned an interception 68 yards for a touchdown early in the second quarter.

CARDINALS 25, LIONS 21: GLENDALE, Ariz. (AP) — A pass interference penalty against Bill Bentley set up Rashard Mendenhall’s 1-yard touchdown run with 1:59 to play in Bruce Arians’ home debut as Cardinals coach.

Jay Feely kicked four field goals and Carson Palmer threw a 36-yard touchdown pass to rookie Andre Ellington for Arizona (1-1). Ellington also had a 16-yard catch to start the deciding drive.

RAVENS 14, BROWNS 6: BALTIMORE (AP) —Baltimore sacked Brandon Weeden five times before finally knocking him out of the game in the fourth quarter.

After yielding 49 points in a season-opening loss at Denver, Baltimore’s defense came up with a redemptive performance against the Browns (0-2). Cleveland failed to score in the second half and managed only 85 yards over the final 30 minutes.

Weeden left with a thumb injury with just over three minutes left and was replaced by Jason Campbell, who could not move the team.