LANDOVER, Md. (AP) — Robert Griffin III dislocated his left ankle and DeSean Jackson sprained his left shoulder in the first quarter, then Kirk Cousins stepped in. He completed 22 of 33 passes for 250 yards and a pair of touchdowns Sunday in Washington’s 41-10 romp past Jacksonville.

Griffin was carted to the locker room with his leg in a splint and could be out for two months. He will undergo X-rays to determine if the ankle is broken.

Cousins subbed for Griffin and completed his first 12 passes. Ryan Kerrigan had four of the Redskins’ 10 sacks, and Washington’s defense didn’t allow Jacksonville (0-2) past midfield until the final two minutes of the first half.

Chargers 30, Seahawks 21

SAN DIEGO (AP) — Antonio Gates had three touchdown catches and the Chargers controlled the tempo to keep Seattle’s offense off the field.

Gates’ 21-yard catch late in the third quarter was epic, as the star tight end split two defenders and extended for Philip Rivers’ pass, reaching out with his left hand to gather it in. Flat on his back, he held up the ball to show the officials he made the catch that gave San Diego a 27-14.

Browns 26, Saints 24

CLEVELAND (AP) — Billy Cundiff kicked a 29-yard field goal with 3 seconds left. Cundiff’s kick helped the Browns (1-1) snap a nine-game losing streak in home openers and gave rookie coach Mike Pettine his first NFL win.

Brian Hoyer drove the Browns 85 yards in 14 plays in the final 2:46 to set up Cundiff’s winner. Hoyer completed several big passes, none more crucial than his 28-yarder to Andrew Hawkins with 13 seconds to go.

Packers 31, Jets 24

GREEN BAY, Wis. (AP) — Aaron Rodgers threw for three touchdowns, Jordy Nelson had a career-high 209 yards receiving and the Packers rallied from an 18-point deficit.

New York appeared to tie it with 5 minutes left on a 37-yard catch by Jeremy Kerley on fourth down — but it was negated because the Jets (1-1) called a timeout from the sideline just before the snap. The Packers (1-1) held on from there to avoid their first 0-2 start since 2006.

Bengals 24, Falcons 10

CINCINNATI (AP) — One Bengals player after another hobbled off and headed to the locker room. They still had more than enough to stay unbeaten with a win over Atlanta (1-1).

Running back Giovani Bernard picked up the depleted offense by running for 90 yards. Cincinnati’s defense held down Matt Ryan and the Bengals won their home opener and improved to 2-0 for the first time since 2006.

Bills 29, Dolphins 10.

ORCHARD PARK, N.Y. (AP) — C.J. Spiller scored on a 102-yard kickoff return, and rookie receiver Sammy Watkins had a 12-yard touchdown catch.

The Dolphins (1-1) also lost a key offseason addition when running back Knowshon Moreno did not return after hurting his left elbow 11 minutes in.

Patriots 30, Vikings 7

MINNEAPOLIS (AP) — Tom Brady and the Patriots took advantage of Adrian Peterson’s absence and Matt Cassel’s four interceptions.

Chandler Jones returned a field goal he blocked for a touchdown right before halftime.

Broncos 24, Chiefs 17

DENVER (AP) — Terrance Knighton batted away Alex Smith’s fourth-and-goal pass to Dwayne Bowe with 15 seconds left.

The Broncos (2-0) thought they had sealed the win twice earlier on the drive. Aqib Talib’s interception return for a touchdown was negated by Quanterus Smith’s hold. Then Nate Irving’s fumble recovery following DeMarcus Ware’s sack and strip was ruled an incomplete pass after a replay.

Panthers 24, Lions 7

CHARLOTTE, N.C. (AP) — Cam Newton made a successful return to the field, throwing for 281 yards and a touchdown. Newton, who missed the season opener with a rib injury, was 22 of 34 and overcame five sacks. Carolina started 2-0 for the first time since 2008.

Trailing 7-6 in the third quarter, the Panthers took advantage of back-to-back Detroit turnovers and scored on three straight possessions.

Cowboys 26, Titans 10

NASHVILLE, Tenn. (AP) — DeMarco Murray ran for 167 yards and a touchdown and Dan Bailey kicked four field goals. The loss spoiled Tennessee first-year coach Ken Whisenhunt’s home debut.

Dallas (1-1) scored the first 16 points of the game in the first half.

Rams 19, Buccaneers 17

TAMPA, Fla. (AP) — Greg Zuerlein’s fourth field goal, a 38-yarder with 38 seconds remaining, gave third-string quarterback Austin Davis and the Rams a tight win.

Davis completed 22 of 29 passes for 235 yards with no interceptions in his first NFL start. Zac Stacy had a 2-yard touchdown run in the first quarter, and Zuerlein also delivered field goals of 36, 35 and 46 yards to help the Rams (1--1) rebound from a lopsided opening loss to Minnesota.

Cardinals 25, Giants 14

EAST RUTHERFORD, N.J. (AP) — Ted Ginn Jr. ran 71 yards on a punt return for a go-ahead fourth-quarter touchdown.

Playing in a regular-season game for the first time since 2010, Drew Stanton replaced the scratched Carson Palmer and led the Cardinals (2-0) on three long scoring drives. Arizona won for the ninth time in 11 games.