CHICAGO (AP) — U.S. midfielder and defender Tyler Adams will miss the CONCACAF Gold Cup because of an injured groin, the third regular starter who will not be available to the struggling American team.

The U.S. Soccer Federation said Tuesday that Adams has acute chronic groin issues requiring six to eight weeks of recovery.

He was replaced on the roster by Dallas defender Reggie Cannon.

Starters DeAndre Yedlin and John Brooks are hurt and missing the tournament, the championship of North and Central America and the Caribbean. Sebastian Lletget, who was contending to start in midfield, also is sidelined.

Coming off a 1-0 loss to Jamaica and a 3-0 defeat to Venezuela, the U.S. opens its Gold Cup title defense against Guyana on June 18 at St. Paul, Minnesota, in the Americans’ first competitive match since the October 2017 loss at Trinidad and Tobago that ended a streak of seven World Cup appearances. They face Trinidad on June 22 at Cleveland and complete group play against Panama on June 26 at Kansas City, Kansas.

The revised roster:

Goalkeepers: Sean Johnson (New York City), Tyler Miller (Los Angeles), Zack Steffen (Columbus).

Defenders: Reggie Cannon (Dallas), Omar Gonzalez (Atlas, Mexico), Nick Lima (San Jose), Aaron Long (New York Red Bulls), Daniel Lovitz (Montreal), Matt Miazga (Chelsea, England), Tim Ream (Fulham, England), Walker Zimmerman (Los Angeles).

Midfielders: Michael Bradley (Toronto), Duane Holmes (Derby, England), Weston McKennie (Schalke, Germany), Christian Pulisic (Chelsea, England), Cristian Roldan (Seattle), Wil Trapp (Columbus).

Forwards: Jozy Altidore (Toronto), Paul Arriola (D.C.), Tyler Boyd (Vitoria Guimares, Portugal), Jonathan Lewis (Colorado), Jordan Morris (Seattle), Gyasi Zardes (Columbus).