Sunday, 1:25 p.m., CBS

OPENING LINE — 49ers by 10

RECORD VS. SPREAD — Buffalo 2-2; San Francisco 3-1

SERIES RECORD — Tied 5-5

AP PRO32 RANKING — Bills No. 20; 49ers No. 3

LAST MEETING — 49ers beat Bills 10-3 ,Nov. 30, 2008

LAST WEEK — Bills lost to Patriots 52-28; 49ers beat Jets 34-0

BILLS OFFENSE — OVERALL (11), RUSH (4), PASS (22)

BILLS DEFENSE — OVERALL (27), RUSH (28), PASS (23)

49ERS OFFENSE — OVERALL (19), RUSH (3), PASS (30)

49ERS DEFENSE — OVERALL (3), RUSH (6), PASS (5)

STREAKS, STATS AND NOTES — Teams have alternated wins in last six matchups. ... Last time either team won consecutive games over other was when San Francisco won in 1983 and 1989. ... RB Brandon Jacobs, out with left knee injury since preseason, could make season debut for 49ers. ... Bills LT Cordy Glenn and RG Kraig Urbik both hurt right ankles in 52-28 loss to New England and not expected to play. ... Game marks first of three straight and five of six at home for San Francisco. .. Trip to Bay Area begins stretch of four of five on road for Buffalo. ... Rather than returning home following game, Bills will travel to Arizona, where they'll practice for week before facing Cardinals. ... Bills WR Stevie Johnson born in San Francisco and attended high school in Fairfax, Calif., just over Golden Gate Bridge in Marin County. ... 49ers S Donte Whitner drafted eighth overall by Buffalo and played for Bills from 2006-10. ... 49ers have not allowed touchdown rushing in 11 straight home games, longest active streak in NFL. ... In winning at Cleveland two weeks ago, Bills snapped eight-game road losing streak. ... Bills QB Ryan Fitzpatrick leads NFL with 12 touchdown passes. He's also tied for second-worst with seven interceptions. ... 49ers QB Alex Smith tied for 14th with five touchdowns. He's tied for second-best with one interception.

___