SAN FRANCISCO (AP) — Wade Miley has been impressive most of the season. One bad outing won't change that, though it's little solace to the young left-hander after throwing a season-low four innings and losing to San Francisco for the second time in 11 days.

Matt Cain pitched seven innings, and had two hits and an RBI to lead the Giants to a 6-0 win over the Arizona Diamondbacks on Wednesday night.

Miley (16-11) will draw some consideration for NL Rookie of the Year honors. After all, he was picked for the All-Star Game and has the most wins in a rookie season since Justin Verlander had 17 in 2006.

"I was not very good at all from the start," Miley said. "I put us in a hole early and it's hard to win games when you're down 4-0 in the second or third inning."

Miguel Montero and Gerardo Parra had two hits apiece for Arizona, which only managed to get one runner past second base while losing for just the third time in 10 games.

"Cain shut us down," Arizona manager Kirk Gibson said. "He could throw any pitch at any time to any place he wants. It was a tough game. We didn't swing the bats well at all."

Miley was attempting to become the first rookie in the NL to reach 17 wins since Cincinnati's Tom Browning in 1985. He didn't come close.

The Giants scored twice off Miley in the third on an infield hit by Sandoval and an RBI single from Buster Posey, who joined Walker Cooper (122 in 1947) and Dick Dietz (107, 1970) as the only other catchers in franchise history to reach 100 RBIs in a season.

"I'm frustrated in myself," Miley said. "I wasn't locating my fastball and missing down. When I made a good pitch, Posey got me last time and he got me again."

Brandon Belt added three hits, Pablo Sandoval singled twice and drove in two runs, and Marco Scutaro extended his career-best hitting streak to 14 games while helping Cain to his career-best 16th win.

It's San Francisco's first victory since clinching the NL West division for the second time in three years.

The Giants were the fifth NL team to pitch a shutout Wednesday. The last time there were at least five shutouts in the same league on the same day was Sept. 18, 2003, in the NL, according to STATS LLC.

Miley lasted just four innings, matching the shortest outing of his career. He allowed three earned runs with three strikeouts and three walks.

Cain singled and scored in the third then reached on an infield single in the fifth to drive in Hunter Pence and make it 5-0. Pence reached on a throwing error by Diamondbacks third baseman Cody Ransom.

Paul Goldschmidt doubled leading off the seventh and moved to third on Parra's single, but Cain worked out of the jam without much trouble. He struck out Ransom and John McDonald then got pinch-hitter Jason Kubel to ground out to third.

Notes: LHP Barry Zito (13-8) goes after his fourth consecutive win for San Francisco in the series finale. LHP Patrick Corbin (6-7) takes the hill for Arizona. ... The Diamondbacks had won four of their previous five games in San Francisco. ... Posey hit a two-run home run against Miley in their last meeting on Sept. 15 in Arizona. ... Montero is 31-87 over his last 23 games (.356) and has reached base safely in 23 consecutive starts.