SAN FRANCISCO (5-2) At ARIZONA (4-3)

Monday, 5:30 p.m., ESPN

OPENING LINE — 49ers by 6½

RECORD VS. SPREAD — San Francisco 4-3; Arizona 3-4

SERIES RECORD — 49ers lead 24-17

AP PRO32 RANKING — 49ers No. 4; Cardinals No. 19

LAST MEETING — Cardinals beat 49ers 21-19, Dec. 11, 2011

LAST WEEK — 49ers beat Seahawks 13-6; Vikings beat Cardinals 21-14

49ERS OFFENSE — OVERALL (9), RUSH (2), PASS (29)

49ERS DEFENSE — OVERALL (1), RUSH (10T), PASS (1)

CARDINALS OFFENSE — OVERALL (31), RUSH (27), PASS (26)

CARDINALS DEFENSE — OVERALL (7), RUSH (20), PASS (4)

STREAKS, STATS AND NOTES — 49ers have allowed 173.4 yards passing per game. Cardinals averaging 204.1 yards passing per game. ... Against Seattle, RB Frank Gore earned 32nd 100-yard rushing game since 2005, most in NFL in that span. ... QB Alex Smith has thrown five interceptions — total he threw all of last season. Four have come in last two games. ... San Francisco has 41 wins Monday night, second only to Dallas (44). .. 49ers 15-4 against NFC West foes since 2009. ... 54 percent of San Francisco's rushing plays have gained at least 4 yards, tops in NFL. ... San Francisco is second in NFL in yards rushing with 1,246. ... Arizona's defense, ranked seventh in NFL and fourth against pass, is just 20th against run, allowing 166 yards rushing vs. Minnesota and 165 against Buffalo in the last two games. ... Cardinals only team not to allow more than 21 points in a game. ... Minnesota QB Christian Ponder was 8 for 17 for 58 yards with one TD and two INTs against Arizona. ... Four teams Cardinals beat to start season all rank above Arizona now in AP Pro32 rankings. ... Cardinals beat San Francisco last season — one of only three 49ers losses — after losing QB Kevin Kolb on first series with what turned out to be season-ending concussion. John Skelton came on to throw for 282 yards and three TDs, with two INTs in 21-19 win. WR Larry Fitzgerald caught seven for 149 yards to top 1,000 yards receiving in season for sixth time in eight years in NFL. Last week in loss to Vikings, Fitzgerald had four catches for 29 yards. ... 49ers win would give them two-game lead over Arizona in NFC West. Arizona win would snap 3-game slide and tie Cardinals with San Francisco atop division standings.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL